IRDye78 Conjugates for Near-Infrared Fluorescence Imaging

Near-Infrared Fluorescence Optical Imaging and Tomography

The advent of recent advances in near-infrared laser diodes and fast electro-optic detection has spawned a new research field of diagnostic spectroscopy and imaging based on targeting and reporting exogenous fluorescent agents. This review seeks to concisely address the physics, instrumentation, advancements in tomography, and near-infrared fluorescent contrast agent development that promises s...

Evaluation of Reflection Optical Imaging Characteristics Using Fluorescence with Near Infrared Wavelength at Different Depths of Tissue Equivalent Phantom

Near-Infrared Fluorescence Imaging for Noninvasive Trafficking of Scaffold Degradation

Biodegradable scaffolds could revolutionize tissue engineering and regenerative medicine; however, in vivo matrix degradation and tissue ingrowth processes are not fully understood. Currently a large number of samples and animals are required to track biodegradation of implanted scaffolds, and such nonconsecutive single-time-point information from various batches result in inaccurate conclusion...

Mouse phenotyping with near-infrared fluorescence lymphatic imaging

We demonstrate the ability to non-invasively and quantitatively image lymphatic architecture and contractile function using dynamic near-infrared (NIR) fluorescence imaging with injection of indocyanine green in normal and transgenic mice. Unlike normal mice, which showed well defined lymphatic drainage patterns and orthograde propagation of contraction waves, we observed tortuous and mispatter...

Near-infrared fluorescence imaging of inflammation in stroke

Brain inflammation is a hallmark of cerebral ischemia, where it has been implicated in tissue damage as well as in repair. Imaging technologies that specifically visualize these processes are highly desirable. In this PhD thesis, the feasibility of planar near-infrared fluorescence (NIRF) imaging to visualize inflammation in a mouse model of focal cerebral ischemia (middle cerebral artery occlu...